Weight loss can feel like an overwhelming journey, especially when diets and exercise alone aren’t giving you the results you deserve. If you’ve been struggling with obesity or find it difficult to manage your appetite, weight loss injections may be a suitable solution. But with different options available—like Mounjaro and Wegovy—you might be wondering: what is the best injection for weight loss, and how do you choose?

At our pharmacy-led weight management service in Manchester, we help patients navigate these choices based on their health profile, lifestyle, and personal goals. In this guide, we’ll break down the key differences between Mounjaro and Wegovy so you can make an informed decision.

Understanding GLP-1 Weight Loss Injections

Both Mounjaro (tirzepatide) and Wegovy (semaglutide) are part of a class of medications called GLP-1 receptor agonists. These medicines work by mimicking the hormone GLP-1, which helps regulate appetite, slow digestion, and improve blood sugar control.

Mounjaro takes it one step further—it also activates GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action appears to enhance its effects on both weight loss and glucose regulation.

Comparing Effectiveness: Mounjaro vs Wegovy

Clinical trials suggest that both Mounjaro and Wegovy can lead to significant weight loss in adults with obesity or a high BMI. However, Mounjaro has shown greater weight loss results in head-to-head studies.

Wegovy: Average weight loss of around 15% of body weight after 68 weeks

Mounjaro: Average weight loss of up to 21% depending on the dose

That said, individual results will vary. Some patients respond better to one medicine over another, depending on genetics, existing conditions, and how consistently the medication is used.

Dosing and Frequency

Both injections are administered once weekly using a prefilled pen, making them convenient and easy to manage from home.

Wegovy starts at 0.25mg and is titrated up to 2.4mg over several weeks.

Mounjaro begins at 2.5mg, increasing in 2.5mg increments every four weeks up to a maximum of 15mg.

Titration schedules are important for minimising side effects, and our clinical team supports you through this process with tailored reviews and dosage plans.

Side Effects to Consider

All GLP-1 medications come with potential side effects, most of which are digestive and tend to improve over time.

Common side effects include:

• –> Nausea

• –> Bloating

• –> Constipation or diarrhoea

• –> Fatigue

• –> Reduced appetite

While these side effects are usually manageable, some patients tolerate one medication better than the other. For example, a patient who experiences persistent nausea on Wegovy may feel more comfortable with Mounjaro—or vice versa.

Severe side effects are rare but should always be monitored. That’s why working with a pharmacy-led weight management service in Manchester ensures you have regular follow-up care and clinical oversight.

Making the Right Choice for You

When asking what is the best injection for weight loss, the answer truly depends on your:

Weight loss goal: Are you aiming for modest weight reduction or significant transformation?

BMI and health history: Some medications may be preferred in patients with diabetes or heart disease.

Side effect profile: Have you used GLP-1 medications before? How well did you tolerate them?

Lifestyle and mindset: Are you prepared to commit to weekly injections, routine follow-ups, and dietary changes?

We never offer a one-size-fits-all approach. Instead, we assess each patient individually to recommend the most suitable medication—whether that’s Mounjaro, Wegovy, or an alternative option. And we don’t stop there. Our service includes lifestyle support, goal setting, and regular check-ins to keep you on track.

What to Expect from Our Weight Management Service in Manchester

Our private programme is designed to offer clinically-led, safe, and effective weight loss support. Patients who come to us benefit from:

• –> A full health and BMI assessment

• –> Prescription of the most appropriate GLP-1 medication

• –> Dose titration planning and side effect management

• –> Ongoing support from our pharmacists and clinicians

• –> Convenient appointments and no long NHS waiting lists

We also support patients looking for private weight loss in Stockport, with flexible appointment options to suit your lifestyle.

Find What Works for You

So, what is the best injection for weight loss? The best one is the one that works best for you. With the guidance of our expert team, you can choose a treatment that suits your needs, manage your health safely, and finally begin a weight loss journey that feels achievable.

If you’re ready to explore whether Mounjaro or Wegovy is right for you, contact our weight management service in Manchester today. Our Everest Pharmacy team will walk you through every step of the process—and help you take control of your weight and your health with confidence.

This blog was written on behalf of Everest Pharmacy by Pharmacy Mentor.