Wegovy vs Mounjaro: What Happens If One Doesn’t Work?

Wegovy vs Mounjaro: What Happens If One Doesn’t Work?

25 / Jul

Starting a weight loss journey with medication can be life-changing, but it’s not always straightforward. While Wegovy and Mounjaro are both highly effective GLP-1 medications, they don’t work in exactly the same way for everyone. Some people respond better to one than the other. So what happens if you’ve been using one and it’s not giving you the results you hoped for?

At Everest Pharmacy, we understand that weight loss is personal. As a trusted Stockport weight loss clinic, we take a tailored, long-term approach to help you reach your goals. If you’re comparing Wegovy vs Mounjaro, or wondering what to do if one isn’t working for you, this guide will walk you through your options.

Why Wegovy or Mounjaro Might Not Work for You

Both Wegovy and Mounjaro are effective, clinically backed medications designed to reduce appetite, improve satiety, and support sustainable weight loss. However, every individual’s response depends on several factors, including:

  • –> Underlying health conditions

  • –> Hormonal and metabolic differences

  • –> Dose progression and consistency

  • –> Lifestyle factors such as diet, sleep, and activity

  • –> Medication adherence and tolerability

Some people may lose weight quickly on Wegovy but plateau after a few months. Others may not respond at all to their starting dose of Mounjaro. It’s important to remember that not seeing results immediately doesn’t mean the treatment has failed, but it does mean it’s time to review your plan with your healthcare provider.

Wegovy vs Mounjaro comparison

Option 1: Adjust the Dose

If your current medication isn’t delivering results, one of the first steps is often a dose review. Both Wegovy and Mounjaro are introduced at lower doses and gradually increased over time. This gradual increase allows your body to adjust while minimising side effects like nausea or fatigue.

At our Stockport weight loss clinic, we carefully track your progress and adjust your dose if necessary — always under the supervision of a trained prescriber. It may be that your body needs more time or a higher therapeutic dose to respond effectively.

Option 2: Switch Medications

If you’ve given the medication time, followed the plan, and still haven’t seen the expected progress, switching from Wegovy to Mounjaro, or vice versa, may be appropriate.

Here’s a basic overview of the differences:

Wegovy (semaglutide): A GLP-1 receptor agonist that mimics the hormone that regulates appetite and blood sugar. It’s usually well-tolerated and ideal for those who need help with appetite control and portion management.

Mounjaro (tirzepatide): A newer medication that acts on both GLP-1 and GIP receptors, offering a dual-action mechanism that may be more effective for some people — especially those with insulin resistance or stubborn weight gain.

Our team offers private weight loss support in Greater Manchester, including expert advice on switching medications safely. We’ll assess your current progress, medical history, and lifestyle to determine whether a different medication could work better for your body.

Option 3: Add Lifestyle Support

Medication alone doesn’t solve every weight loss challenge. For many patients, complementary lifestyle support makes all the difference.

At Everest Pharmacy, we work with you to build habits that support long-term results, including:

  • –> Tailored dietary advice and calorie planning

  • –> Behavioural support for emotional or stress-related eating

  • –> Exercise recommendations suited to your fitness level

  • –> Sleep and hydration tracking

  • –> Gut health and digestive support if side effects are affecting your routine

We can also help with realistic goal-setting and check-ins to keep you motivated, especially if you’re struggling with slower-than-expected progress.

Wegovy vs Mounjaro for weight loss.

Option 4: Explore Underlying Causes

If neither Wegovy nor Mounjaro is helping after proper dosing and lifestyle changes, it may be time to investigate deeper. Underlying medical conditions such as thyroid dysfunction, PCOS, insulin resistance, or undiagnosed metabolic syndrome could be slowing your progress.

As part of our private weight loss support in Greater Manchester, we can provide blood tests and refer you to specialist services for further investigation. Identifying and treating these issues can often unlock more effective weight loss responses — with or without medication.

A Long-Term Partner in Your Weight Loss Journey

At Everest Pharmacy, we don’t take a one-size-fits-all approach. As a trusted Stockport weight loss clinic, we pride ourselves on providing personalised support, compassionate care, and expert guidance throughout your treatment.

Whether you’re just starting out with Wegovy or Mounjaro, or you’re unsure what to do next, we’re here to help you make informed decisions and stay supported every step of the way.

Drop in to one of our branches or reach out today to get guidance and support from our dedicated team.

Ready to Reassess Your Treatment?

If you’re not seeing the results you expected from your current medication, don’t give up. Whether it’s time to adjust your dose, switch from Wegovy to Mounjaro, or dig deeper into your health, Everest Pharmacy is ready to help.

Book your weight loss consultation today and take control of your journey with confidence and expert support.

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This blog was written on behalf of Everest Pharmacy by Pharmacy Mentor.